COMPLEMENT FIXATION TEST FOR THE LANSING STRAIN OF POLIOMYELITIS VIRUS
نویسندگان
چکیده
منابع مشابه
A Specific Complement-fixation Test for Infection with Poliomyelitis Virus
A complement-fixing antigen has been developed, using as source of material CNS tissue from newborn mice infected with the newborn mouse-adapted strain of the Lansing type, MEF1 virus. With this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the Lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this...
متن کاملComplement fixation test using the antigen prepared from the nervous tissue of adult mice infected with poliomyelitis virus Lansing type.
The technique of complement fixation test as a measure for the serological diagnosis of neurotropic virus infections was first put in practice by Casals and Palacios (1) in the year 1941, and confirmed of its practical diagnostic value by numerous follow-ups made after it. In spite of repeated attempts, the application of this technique for the diagnosis of poliomyelitis had not been successful...
متن کاملA Complement Fixation Test for Poliomyelitis
A macroscopic (tube) complement fixation test for poliomyelitis, using infected tissue culture fluids, is described. The test was applied to 27 individuals with a clinical diagnosis of poliomyelitis. In 18 patients it was possible to make a laboratory diagnosis of poliomyelitis on the basis of a rise in complement-fixing antibody titer and in 4 others on the basis of a high stationary antibody ...
متن کاملComplement Fixation Tests in Poliomyelitis **
Infection with poliomyelitis virus gives rise to complement-fixing (C-F) antibodies which may be detected with antigens prepared either from the brains of infected mice or tissue culture fluids, as shown with Type II by Casals et al."' and with all three types by Svedmyr et al.' These workers used sufficient antigen in each test to obtain maximum sensitivity. With this antigen concentration the...
متن کاملAdaptation of a Lansing Strain of Poliomyelitis Virus to Newborn Mice
By means of rapid serial passages, including 3 successive "blind" passages, the MEF1 strain, a Lansing-type poliomyelitis virus, has been adapted to new-born mice. The virus can readily be propagated in newborn mice, in which fully adapted virus induces in almost all inoculated animals the experimental disease, resulting in a much greater infectivity for the central nervous system and a uniform...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: VIRUS
سال: 1952
ISSN: 1884-3425
DOI: 10.2222/jsv1951.2.215